About
Contained in nearly every cell type of the body are tiny structures called mitochondria. These pill-shaped organelles play a key role in metabolism, growth and muscle function and provide the energy needed for good health. Defects in mitochondria can result in serious, sometimes fatal, diseases.
The Biodesign Center for Bioenergetics focuses on improved diagnosis and treatment for diseases caused by mitochondrial defects. The majority of these diseases are degenerative and affect children and young adults. Characteristics include suboptimal heart and muscle function, speech problems and developmental delays. Dysfunctional mitochondria are associated with Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, ataxias, diabetes and cancer.
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People
Bio
Sidney M. Hecht is the director for the Center for BioEnergetics in the Biodesign Institute at Arizona State University. He researches diseases caused by defects in the body’s energy production processes. Energy production is similar mechanistically to other molecular processes that he has studied extensively. He played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin.
In a career spanning more than three decades, Professor Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a B.A. in chemistry from the University of Rochester and a Ph.D. in chemistry with emphasis in biochemistry from the University of Illinois.
On The Web
Website: https://biodesign.asu.edu/bioenergetics/profile/smhecht/