In our laboratory, we have two broad, intertwined objectives. The first is to gain insight into the normal physiology of mitochondria and glucose metabolism in the brain, with a particular focus on bioenergetics, mitochondrial dynamics, and quality control in neurons. The second is to understand how disrupting mitochondrial function and metabolism contributes to neurodegenerative diseases, especially Parkinson’s disease (PD), Alzheimer’s disease (AD), and mitochondrial disorders, and to use these insights to develop new approaches to target energy metabolism therapeutically.

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