About
The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our research group is interested in fundamental questions related to mitochondrial biology. How is the number and the function of mitochondria regulated? What happens in a cell with dysfunctional mitochondria? How does mitochondrial dysfunction cause human disease?
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Bio
My interest in mitochondrial biology started in 1987 when I began my PhD studies of pathogenic mtDNA mutations causing mitochondrial disease in humans. I decided to get proper training in biochemistry and mouse genetics and went to Stanford University as a HHMI Physician Postdoctoral Fellow in 1994. When I returned to Sweden in 1997, I started my own research group at Karolinska Institutet and developed a series of powerful mouse models. In 2008, I was recruited as one of the founding Directors to the new Max Planck Institute for Biology of Ageing in Cologne, Germany. Between 2008 and 2015, I remained affiliated to KI and kept a small research group here. In 2016, I was recruited back to have KI as my main working place. From 2019, I will be an external member of the Max Planck Society.